The plan is the result of the hard and many dedicated iciq researchers, technicians, management and administration staff members. Paolo melchiorre, iciq group leader has been awarded a european research council erc proof of concept grant for the development of the lightcoat project. Photochemical generation of radicals from alkyl electrophiles. Paolo melchiorre was born in 1973 in camerino, italy. Herein we describe our efforts to elucidate the key mechanistic aspects of the previously reported enantioselective photochemical. Visiblelight triggered the photoinduced generation of iodomethyl carbonyl radicals, able to cyclopropanate a wide array of styrenes with excellent chemoselectivity a editors choice paolo melchiorre.
A visiblelight mediated threecomponent radical process using. Disclosed herein is a photochemical organocatalytic strategy for the direct enantioselective mannichtype reaction of 2alkylbenzophenones and cyclic imines. With an economic endowment worth 150,000, lightcoat aims to provide a new class of photoinitiators, which will be able to trigger polymerization reactions at room temperature and using visible light. Escuderoadan,a and paolo melchiorrea,b a iciq institute of chemical research of catalonia, av. He now works as a postdoctoral researcher at the university of oxford uk in the group of veronique gouverneur. Aminocatalytic enantioselective 1,6 additions of alkyl. M bandini, pg cozzi, m giacomini, p melchiorre, s selva. In september 2009 paolo joined the institute of chemical research of catalonia iciq in tarragona as an icrea catalan institution of research and advanced studies professor and iciq group leader. Asymmetric photocatalytic ch functionalization of toluene. The second japanesespanish symposium on organic synthesis supported by a grantinaid for scientific research on innovative areas hybrid catalysis from the ministry of education, culture. The photochemical activity of electron donoracceptor eda complexes provides a way to generate radicals under mild conditions. For a long time, because of its high reactivity and fleeting nature, a could not be trapped in a stereosel.
Radical route for the synthesis of chiral molecules. Pdf document this is the author accepted manuscript aam. Organocatalytic strategies to stereoselectively trap. October 2007 assistant professor ricercatore at bologna university alma mater studiorum bologna italy dept.
Catalan institution for research and advanced studies, pg. Here, we show that primary amine catalysis provides an efficient way to address this synthetic issue, promoting vinylogous. A combination of electrochemical, spectroscopic, computational, and kinetic studies has been used to elucidate the key mechanistic aspects of the previously reported enantioselective iminium ion trapping of photochemically generated carboncentered radicals. Enantioselective organocatalytic alkylation of aldehydes and enals driven by the direct photoexcitation of enamines mattia silvi, elena arceo, igor d. Hepburn a and paolo melchiorre ab a iciq institute of chemical research of catalonia, the barcelona institute of science and technology, av. New catalytic methods for the synthesis of relevant molecules through the activation of inert entities. Enhancing the potential of organocatalysis with light. Paolo melchiorre iciq, has defended her phd thesis entitled exploiting organocatalysis in photochemical processes assigned to the department of analytic and organic chemistry of the universitat rovira i virgili publicly on october 17 th at the iciq auditorium. Photoorganocatalytic enantioselective perfluoroalkylation of. General information the 1h and c nmr spectra were recorded at 400 mhz and 500 mhz for 1h or at 100 mhz and 125 mhz for c, respectively. Jun 17, 2019 apply online with the following documents. Erc proof of concept grant awarded to paolo melchiorre. Photoorganocatalytic enantioselective perfluoroalkylation.
The chemistry exploits the potential of chiral enamines. European journal of organic chemistry wiley online library. The research domain of chemical sciences is growing at a phenomenal pace. The reaction requires exceptionally mild reaction conditions to proceed, as it occurs at ambient temperature and.
Paolo ha indicato 14 esperienze lavorative sul suo profilo. Please join us for our 2nd edition at 2pm cet on april 22nd, 2020 for three 25minute presentations by paolo melchiorre iciq, tarragona, cristina nevado. Jerome blanchet university of caen lcmt, france dr. Enantioselective organocatalytic alkylation of aldehydes and. Visiblelight excitation of iminium ions enables the enantioselective catalytic. An operationally simple and broadly applicable novel cyclopropanation of styrenes using gemdiiodomethyl carbonyl reagents has been developed. The institute of chemical research of catalonia is a private foundation governed by the following bodies. An important goal of modern organic chemistry is to develop new catalytic strategies for enantioselective carboncarbon bond formation that can be used to.
Research supported by the iciq foundation, mineco project ctq2045938p, sev20319, the agaur 2014 sgr 1059, and the european research council erc 681840 catalux cbc seminar announcement professor paolo melchiorre institute of chemical research of catalonia enantioselective photoorganocatalysis. Editorial board industrial advisory board academic. Please join us for our 2nd edition at 2pm cet on april 22nd, 2020 for three 25 minute presentations by paolo melchiorre iciq, tarragona, cristina nevado. Sep 22, 2014 we have found that an organic molecule as simple as p. Sara cuadros, phd student under the supervision of prof.
Jurberg, carlo cassani, and paolo melchiorre, iciq. Murphy, and paolo melchiorre iciq institute of chemical research of catalonia, av. Paolo melchiorre reported herein is a visiblelightmediated organocatalytic direct ch functionalization of toluene derivatives to afford enantioenriched. Carbon types were determined from dept c nmr experiments.
Paolo melchiorre istituto italiano di tecnologia iit genova. Specifically, the 1,6 addition of alkyl thiols to substituted cyclic dienones was catalyzed by a cinchona. Opening awards ceremony giorgio modena award lectures. The phd candidates will be working on the supramolecular detection field using molecular and supramolecular synthetic receptors for their application in the development of. Enantioselective radical conjugate additions driven by a. Europe pmc is an archive of life sciences journal literature.
S1 multiple approaches to enantiopure spirocyclic benzofuranones using organocatalytic cascade reactions carlo cassani,a xu tian,a eduardo c. Asymmetric catalytic formation of quaternary carbons by. The board of trustees is the senior body with regard. In spite of the many catalytic methodologies available for the asymmetric functionalization of carbonyl compounds at their. Aug 16, 2018 the photochemical activity of electron donoracceptor eda complexes provides a way to generate radicals under mild conditions. The ones marked may be different from the article in the profile. Daniele leonori university of manchester, uk enzyme processes to introduce and oxidise oxy functionalities. Paolo tecilla university of trieste paolo scrimin, university of padova giorgio modena. Bronsted acidcatalysed conjugate addition of photochemically generated. Paolo melchiorre senior software engineer 20tab srl. Paolo melchiorre iciq, institut catala dinvestigacio quimica, es. Miller, yale university, new haven, ct usa cristina nevado, university of zurich, zurich switzerland kyoko nozaki, university of tokyo, tokyo japan melanie sanford, university of michigan, ann arbor, mi usa brian m.
The recipient of this award delivers a lecture and receives a commemorative medal in an. The final published version version of record is available online. Natures inherent chirality requires us to create when. Heteroaryl bromides nurtalya alandini, luca buzzetti. Apr, 2016 an important goal of modern organic chemistry is to develop new catalytic strategies for enantioselective carboncarbon bond formation that can be used to generate quaternary stereogenic centres. The process combines the oxidative power of a chiral excitedstate iminium ion and the basic nature of its counteranion to trigger the generation of benzylic radicals by means of a sequential multisite. The institute of chemical research of catalonia iciq institutes the phd fellowship programme with the aim to support excellent students from all over the world to enroll in a training and research programme in the area of chemistry ultimately leading to the completion of a doctoral thesis in partnership with the universitat rovira i virgili urv.
Aminocatalytic enantioselective 1,6 additions of alkyl thiols. Photochemical processes considerably enrich the modern synthetic repertoire, offering a potent way to build complex organic frameworks 1. Our goal is to make available to iciq s staff the resources and tools necessary to carry out an inclusive science for a. In 2003, paolo worked as a postdoctoral associate with professor giuseppe bartoli. Thanks to this novel approach, triggered by visible light, we. Mechanistic studies in photocatalysis buzzetti 2019. Dedicated to professor dieter enders on the occasion of his 70 th birthday. Our goal is to make available to iciq s staff the resources and tools necessary to carry out an inclusive science for a sustainable society. Enantioselective organocatalytic alkylation of aldehydes.
Studies on the enantioselective iminium ion trapping of. Reported herein is a visiblelightmediated organocatalytic direct ch functionalization of toluene derivatives to afford enantioenriched. Paolo melchiorre institute of chemical research of. Alkylation of enals mattia silvi, charlie verrier, yannick rey, luca buzzetti and paolo melchiorre.
Mar 20, 2017 europe pmc is an archive of life sciences journal literature. Paolo melchiorre organocatalysiscatalysis mediated by small chiral organic moleculesis a powerful technology for enantioselective synthesis, and has extensive applications in traditional ionic. Stoltz, california institute of technology, pasadena, ca usa. This cited by count includes citations to the following articles in scholar. Bronsted acidcatalysed conjugate addition of photochemically. Jun 29, 2016 herein we describe our efforts to elucidate the key mechanistic aspects of the previously reported enantioselective photochemical. Paolo melchiorre princeton university department of. Hepburn, alberto vegapenaloza, mattia silvi and paolo melchiorre acs catalysis, 2018, 8, 10621066. Multiple approaches to enantiopure spirocyclic benzofuranones.
This strategy has found application in chemical synthesis and. Radical route for the synthesis of chiral molecules 14 april 2016 prof. This website uses cookies to facilitate user navigation. Spectroscopic conformational analyses were crucial to understanding how the. Cv in pdf format including the academic background, labour or research experience, publications, conferences, grants and awards, previous participation in iciq programmes, other relevant merits and references. May 06, 2015 photoorganocatalytic enantioselective perfluoroalkylation of. It is necessary to organize symposia and conferences on various aspects of it at regular. Direct asymmetric vinylogous michael addition of cyclic. Paolo melchiorre organocatalysis, photocatalysis, kilian muniz activation and transformation of nitrogen compounds and vladimir v. Pdf photoorganocatalytic enantioselective radical cascade.
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